Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
Lipids, Lipoproteins, and Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. A prominent age-related change is the accumulation of neutral lipid in normal Bruch's membrane (BrM) throughout adulthood and also disease-re...
متن کاملTargeting Tissue Lipids in Age-related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness among people over 50 years of age in the industrialized world (van Leeuwen et al., 2003). A cardinal clinical feature of the disease is extracellular deposition of lipid-rich deposits underneath the retinal pigmented epithelium (RPE) called drusen, which contain high amounts of esterified and unesterified cholesterol (Curc...
متن کاملcorrelation between serum lipids and age-related macular degeneration: a case-control study
background: age-related macular degeneration (amd) is one of the leading causes of visual loss among people aged 65 yr and older. the pathophysiology of amd is poorly understood. the purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration. methods: in this case-control study, total cholesterol (tch), low density lipoprotein ...
متن کاملCorrelation between serum lipids and age-related macular degeneration: a case-control study.
BACKGROUND Age-related macular degeneration (AMD) is one of the leading causes of visual loss among people aged 65 yr and older. The pathophysiology of AMD is poorly understood. The purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration. METHODS In this case-control study, total cholesterol (TCH), low density lipoprotein ...
متن کاملThe Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration
Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein choles...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2017
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2016.07.013